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Application of near Infrared Spectroscopy in Biomedicine
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  • Application of near Infrared Spectroscopy in Biomedicine
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  • Springer New York, NY 2013 ©2013
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  • 1 online resource (155 pages)
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  • Intro -- Application of NearInfrared Spectroscopyin Biomedicine -- Preface -- Contents -- Contributors -- 1. Principles and Instrumentation: -- 1.1 Light Absorption and Light Scattering -- 1.2 Optical Properties of Tissue -- 1.3 Near-Infrared Spectroscopy -- 1.4 Continuous-Wave NIRS -- 1.5 Spatially Resolved NIRS -- 1.6 Time-Resolved NIRS -- 1.7 Phase-Modulated NIRS -- Problem -- Further Reading -- References -- 2. Photon Migration in Tissue: -- 2.1 Introduction -- 2.2 Photon Diffusion Theory -- 2.2.1 Homogeneous Media -- 2.2.2 Inhomogeneous Media -- 2.3 Monte Carlo Methods -- 2.4 Models for Monte Carlo Simulation -- 2.5 Calculation of Spatial Sensitivity -- 2.6 Photon Migration in Layered Tissues -- 2.7 Effect of Fat Layer -- 2.8 Effect of Skin -- 2.9 Analysis of Time-Resolved Measurement -- 2.10 Analysis of Spatially Resolved Measurement -- Problem -- Further Reading -- References -- 3. Photon Migration in NIRS Brain Imaging: -- 3.1 Introduction -- 3.2 Important Physical Parameters for NIRS -- 3.2.1 Modified Beer-Lambert Law -- 3.2.2 Partial Optical Pathlength -- 3.2.3 Spatial Sensitivity Profile -- 3.3 Brain-Function Imaging by NIRS -- 3.3.1 Tomography and Topography -- 3.3.2 Reconstruction Method -- 3.3.3 Mapping Method -- 3.4 Head Models for Photon-Migration Analysis -- 3.4.1 Optical Heterogeneity of Head -- 3.4.2 Simplified Head Model and Realistic Head Model -- 3.5 Simulation Methods of Photon Migration -- 3.5.1 Monte Carlo Method -- 3.5.2 Diffusion Equation -- 3.6 Influence of Superficial Tissues on Photon Migration in Brain -- 3.6.1 Influence of Optical Properties -- 3.6.2 Influence of Thickness of Superficial Layers -- 3.6.3 Applicability of Diffusion Equation -- 3.7 Modeling of NIRS Topography -- 3.8 Summary -- Problems -- Further Reading -- References -- 4. Clinical Application of NIRS: -- 4.1 Introduction -- 4.2 Muscle Metabolism
  • 4.2.1 Exercise Prescription/Training Effects -- 4.2.2 Congestive Heart Failure and Q10 Deficiency -- 4.3 Vessel Function -- 4.3.1 Arterial Function -- 4.3.2 Microvascular Function -- 4.4 Brain Function -- 4.4.1 Vascular Dementia -- 4.4.2 Brain Oxygenation during Surgery -- 4.4.3 Brain Oxygenation in Children -- 4.5 Cancer Detection -- 4.5.1 Breast Tissue -- 4.5.2 Skin Lesion -- 4.5.3 Therapeutic Application -- 4.6 Others -- 4.7 Summary -- Problem -- Further Reading -- References -- 5. In-Vivo NIRS and Muscle Oxidative Metabolism -- 5.1 Introduction -- 5.2 Biochemistry and Physiology of Muscle Oxidative Metabolism -- 5.3 Principles of Muscle NIRS -- 5.4 Quantification of In-Vivo NIRS Measurements -- 5.4.1 Mb/Hb -- 5.4.2 Effect of Multiple Layers -- 5.5 In-Vitro and In-Vivo Calibration of NIRS Measurements -- 5.6 Application of NIRS to Physiological Science -- 5.7 Application of NIRS to Clinical Practice -- 5.7.1 Congestive Heart Failure (CHF) -- 5.7.2 Patients with Chronic Obstructive Pulmonary Disease (COPD) -- 5.7.3 Neuromuscular Disorders -- 5.7.4 Peripheral Arterial Disease (PAD) -- 5.7.5 Spinal Cord Injury (SCI) -- 5.7.6 End-Stage Renal Disease (ESRD) -- 5.8 Summary -- Problems -- Further Reading -- References -- 6. Intracellular Oxygen Dynamics Observed by NIRS During Skeletal Muscle Contraction -- 6.1 Introduction -- 6.2 Spectral Properties of Mb and Hb Ex Vivo -- 6.3 Preparation of Hindlimb Perfusion -- 6.4 Mb Desaturation During Skeletal Muscle Contraction -- 6.5 Calculation of Intracellular PO2 Equivalent with SMbO2 -- 6.6 Evaluation of Mb-Associated O2 Dynamics -- 6.7 Intracellular O2 Flux Released from Mb -- 6.8 O2 Gradient and O2 Flux with Muscle Contraction -- 6.9 Myoglobin Function in Muscle Cells -- 6.10 Mb Contribution to O2 Transport In Vivo -- 6.11 Mb-Facilitated Diffusion and Skeletal Muscle Function -- 6.12 Summary -- Problem
  • Further Reading -- References -- 7. Muscle Oxygen Saturation Measurements in Diving Mammals and Birds Using NIRS -- 7.1 Introduction -- 7.2 Background -- 7.3 Development of Novel Instruments Using NIRS -- 7.3.1 NIR Reflectance Spectroscopy and Mb Absorption Spectra -- 7.3.2 Linearity Validation and NIRS Signal Calibration -- 7.3.3 Implant Site -- 7.3.4 Experimental Evaluation of Instrument -- 7.4 Summary of NIRS Studies of Diving Mammals and Birds -- 7.4.1 Muscle O2 Depletion in Weddell Seals -- 7.4.2 Muscle O2 Depletion in Emperor Penguins -- 7.4.3 Muscle O2 Depletion in Trained Harbor Seals -- 7.5 Other Considerations in Instrument Design -- 7.5.1 Probe Placement -- 7.5.2 Sampling Rate -- 7.6 Summary -- Problem -- Further Reading -- References -- 8. Noninvasive NMR and NIRS Measurement of Vascular and Intracellular Oxygenation In Vivo -- 8.1 Introduction -- 8.2 Microelectrode Measurement of Vascular and Intracellular Oxygenation -- 8.3 Spectroscopic Approaches -- 8.4 Hb Absorbance of Visible Light -- 8.5 Mb Absorbance of Visible Light -- 8.6 Near-Infrared Versus Visible Light Scattering -- 8.7 Interference from Fat Layer -- 8.8 Overlapping Mb and Hb Signals -- 8.9 NMR -- 8.10 Assignment of the Proximal Histidyl NδH -- 8.11 Assignment of the Val E11 CH3 Signal -- 8.12 NMR and Measurement of Tissue Oxygenation -- 8.13 Mechanism of Respiratory Control -- 8.14 Summary -- Problems -- Further Reading -- References -- 9. Problem Solutions -- Chapter 1 -- Chapter 2 -- Chapter 3 -- Chapter 4 -- Chapter 5 -- Chapter 6 -- Chapter 7 -- Chapter 8 -- Index
Anmärkning: Innehållsbeskrivning, sammanfattning
  • This volume balances the need for physical science/mathematics formalism with a demand for biomedical perspectives. It details current instrumentation and techniques as well as illustrates current applications in addressing complex biology questions.
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  • Print version: Jue, Thomas Application of near Infrared Spectroscopy in Biomedicine New York, NY : Springer,c2013 ISBN 9781461462514
Seriebiuppslag under titel
  • Handbook of Modern Biophysics Ser.
ISBN
  • 9781461462521
 
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