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*100  $aSherlock, Shiela.
*24510$aDiseases of the Liver and Biliary System
*250  $a11
*264 1$aChichester$bJohn Wiley & Sons, Incorporated$c2002
*264 4$c©2008
*300  $a1 online resource (724 pages)
*336  $atext$btxt$2rdacontent
*337  $acomputer$bc$2rdamedia
*338  $aonline resource$bcr$2rdacarrier
*505 0$aDiseases of the Liver and Biliary System -- Contents -- Preface to the Eleventh Edition -- Preface to the First Edition -- 1. Anatomy and Function -- Functional anatomy: sectors and segments -- Anatomy of the biliary tract -- Development of the liver and bile ducts -- Anatomical abnormalities of the liver -- Surface marking -- Methods of examination -- Hepatic morphology -- Electron microscopy and hepato-cellular function -- Sinusoidal cells -- Hepatocyte death and regeneration -- Extra-cellular matrix -- Altered hepatic microcirculation and disease -- Adhesion molecules -- Functional heterogeneity -- Sinusoidal membrane traffic -- Bile duct epithelial cells -- 2. Assessment of Liver Function -- Selection of biochemical tests -- Bile pigments -- Bilirubin -- Urobilinogen -- Bromsulphalein -- Serum enzyme tests -- Alkaline phosphatase -- Gamma glutamyl transpeptidase -- Aminotransferases -- Other serum enzymes -- Quantitative assessment of hepatic function -- Galactose elimination capacity -- Breath tests -- Salivary caffeine clearance -- Lignocaine metabolite formation -- Arterial blood ketone body ratio -- Antipyrine -- Indocyanine green -- Asialoglycoprotein receptor -- Excretory capacity (BSP) -- Lipid and lipoprotein metabolism -- Lipids -- Lipoproteins -- Changes in liver disease -- Bile acids -- Changes in disease -- Serum bile acids -- Amino acid metabolism -- Clinical significance -- Plasma proteins -- Electrophoretic pattern of serum proteins -- Carbohydrate metabolism -- Effects of ageing on the liver -- 3. Biopsy of the Liver -- Selection and preparation of the patient -- Techniques -- Difficulties -- Liver biopsy in paediatrics -- Risks and complications -- Pleurisy and peri-hepatitis -- Haemorrhage -- Intra-hepatic haematomas -- Haemobilia -- Arteriovenous fistula -- Biliary peritonitis -- Puncture of other organs -- Infection
*505  $aCarcinoid crisis -- Sampling variability -- Naked eye appearances -- Preparation of the specimen -- Interpretation -- Indications -- Special methods -- 4. The Haematology of Liver Disease -- General features -- The liver and blood coagulation -- Haemolytic jaundice -- The liver in haemolytic anaemias -- Hereditary spherocytosis -- Thalassaemia -- Paroxysmal nocturnal haemoglobinuria -- Acquired haemolytic anaemia -- Haemolytic disease of the newborn -- Incompatible blood transfusion -- The liver in myelo- and lymphoproliferative disease -- Leukaemia -- Myeloid -- Lymphoid -- Hairy cell leukaemia -- Bone marrow transplantation -- Lymphoma -- Jaundice in lymphoma -- Primary hepatic lymphoma -- Lymphosarcoma -- Multiple myeloma -- Angio-immunoblastic lymphadenopathy -- Extra-medullary haemopoiesis -- Systemic mastocytosis -- Langerhans' cell histiocytosis (histiocytosis X) -- Lipid storage diseases -- Primary and secondary xanthomatosis -- Cholesteryl ester storage disease -- Gaucher's disease -- Niemann-Pick disease -- Sea-blue histiocyte syndrome -- 5. Ultrasound, Computed Tomography and Magnetic Resonance Imaging -- Radio-isotope scanning -- Positron emission tomography (PET) -- Ultrasound -- Doppler ultrasound -- Endoscopic ultrasound -- Computed tomography -- Magnetic resonance imaging -- MR spectroscopy -- Conclusions and choice -- 6. Hepato-cellular Failure -- General failure of health -- Jaundice -- Vasodilatation and hyperdynamic circulation -- Hepato-pulmonary syndrome -- Pulmonary hypertension -- Fever and septicaemia -- Fetor hepaticus -- Changes in nitrogen metabolism -- Skin changes -- Vascular spiders -- Palmar erythema (liver palms) -- White nails -- Mechanism of skin changes -- Endocrine changes -- Hypogonadism -- Hypothalamic-pituitary function -- Metabolism of hormones -- General treatment -- Precipitating factors -- General measures
*505  $a7. Hepatic Encephalopathy -- Clinical features -- Investigations -- Neuropathological changes -- Clinical variants in cirrhotics -- Differential diagnosis -- Prognosis -- Pathogenetic mechanisms -- Portal-systemic encephalopathy -- Intestinal bacteria -- Neurotransmission -- Conclusions -- Treatment of hepatic encephalopathy -- Diet -- Antibiotics -- Lactulose and lactilol -- Sodium benzoate and L-ornithine -L-aspartate -- Levodopa and bromocriptine -- Flumazenil -- Branched-chain amino acids -- Other precipitating factors -- Shunt occlusion -- Temporary hepatic support -- Hepatic transplantation -- 8. Acute Liver Failure -- Definition -- Causes -- Clinical features -- Investigations -- Associations -- Prognosis -- Treatment -- Conclusion -- 9. Ascites -- Mechanism of ascites formation -- Underfill and peripheral vasodilatation hypotheses -- Overfill hypothesis -- Other renal factors -- Circulation of ascites -- Summary -- Clinical features -- Spontaneous bacterial peritonitis -- Treatment of cirrhotic ascites -- Refractory ascites -- Prognosis -- Hepato-renal syndrome -- Hyponatraemia -- 10. The Portal Venous System and Portal Hypertension -- Collateral circulation -- Intra-hepatic obstruction (cirrhosis) -- Extra-hepatic obstruction -- Effects -- Pathology of portal hypertension -- Varices -- Portal hypertensive intestinal vasculopathy -- Haemodynamics of portal hypertension -- Clinical features of portal hypertension -- History and general examination -- Abdominal wall veins -- Spleen -- Liver -- Ascites -- Rectum -- X-ray of the abdomen and chest -- Barium studies -- Endoscopy -- Imaging the portal venous system -- Ultrasound -- Doppler ultrasound -- CT scan -- Magnetic resonance angiography -- Venography -- Venographic appearances -- Visceral angiography -- Digital subtraction angiography -- Splenic venography -- Carbon dioxide wedged venography
*505  $aPortal pressure measurement -- Variceal pressure -- Estimation of hepatic blood flow -- Azygos blood flow -- Experimental portal venous occlusion and hypertension -- Classification of portal hypertension -- Extra-hepatic portal venous obstruction -- Aetiology -- Clinical features -- Prognosis -- Treatment -- Splenic vein obstruction -- Hepatic arterio-portal venous fistulae -- Porto-hepatic venous shunts -- Intra-hepatic pre-sinusoidal and sinusoidal portal hypertension -- Portal tract lesions -- Toxic causes -- Hepato-portal sclerosis -- Tropical splenomegaly syndrome -- Intra-hepatic portal hypertension -- Cirrhosis -- Non-cirrhotic nodules -- Bleeding oesophageal varices -- Predicting rupture -- Prevention of bleeding -- Diagnosis of bleeding -- Prognosis -- Management of acute variceal bleeding -- Vaso-active drugs -- Sengstaken-Blakemore tube -- Endoscopic sclerotherapy and banding -- Emergency surgery -- Prevention of re-bleeding -- Portal-systemic shunt procedures -- Porta-caval -- Meso-caval -- Selective 'distal' spleno-renal -- General results of portal-systemic shunts -- TIPS (transjugular intrahepatic portosystemic shunt) -- Shunt stenosis and occlusion -- Control of bleeding -- TIPS encephalopathy -- Circulatory changes -- Other indications -- Conclusions -- Hepatic transplantation -- Pharmacological control of the portal circulation -- Conclusions -- 11. The Hepatic Artery and Hepatic Veins: the Liver in Circulatory Failure -- The hepatic artery -- Hepatic artery occlusion -- Hepatic arterial lesions following liver transplantation -- Aneurysms of the hepatic artery -- Hepatic arteriovenous shunts -- The hepatic veins -- Experimental hepatic venous obstruction -- Budd-Chiari (hepatic venous obstruction) syndrome -- Pathological changes -- Clinical features -- Diagnosis -- Prognosis -- Treatment -- Veno-occlusive disease
*505  $aSpread of disease by the hepatic veins -- Circulatory failure -- Hepatic changes in acute heart failure and shock -- Ischaemic hepatitis -- Post-operative jaundice -- Jaundice after cardiac surgery -- The liver in congestive heart failure -- The liver in constrictive pericarditis -- 12. Jaundice -- Bilirubin metabolism -- Hepatic transport and conjugation of bilirubin -- Distribution of jaundice in the tissues -- Factors determining the depth of jaundice -- Classification of jaundice -- Diagnosis of jaundice -- Clinical history -- Examination -- Diagnostic routine -- Familial non-haemolytic hyperbilirubinaemias -- Primary hyperbilirubinaemia -- Gilbert's syndrome -- Crigler-Najjar syndrome -- Dubin-Johnson syndrome -- Rotor type -- The group of familial non-haemolytic hyperbilirubinaemias -- 13. Cholestasis -- Anatomy of the biliary system -- Secretion of bile -- Cellular mechanisms -- Syndrome of cholestasis -- Definition -- Classification -- Pathogenesis -- Pathology -- Clinical features -- Diagnostic approach -- Diagnostic possibilities -- 14. Primary Biliary Cirrhosis -- Aetiology -- Epidemiology and genetics -- Clinical features -- Diagnosis -- Prognosis -- Treatment -- Immune cholangiopathy -- Autoimmune cholangitis -- 15. Sclerosing Cholangitis -- Primary sclerosing cholangitis -- Infective sclerosing cholangitis -- Bacterial cholangitis -- Immunodeficiency-related opportunistic cholangitis -- Graft-versus-host disease -- Vascular cholangitis -- Drug-related cholangitis -- Histiocytosis X -- 16. Viral Hepatitis: General Features, Hepatitis A, Hepatitis E and Other Viruses -- Pathology -- Clinical types -- Investigations -- Differential diagnosis -- Prognosis -- Treatment -- Follow-up -- Hepatitis A virus -- Epidemiology -- Clinical course -- Prognosis -- Prevention -- Hepatitis E virus -- Clinical features -- Diagnostic tests -- Liver biopsy
*505  $aPrevention
*520  $aDiseases of the Liver and Biliary System continues to be the pre-eminent textbook of choice for trainee as well as practising gastroenterologists who want a clear and lucid description of the very latest issues in this growing discipline. Every chapter has been updated with the most recent advances in the study and control of hepatitis, in its various forms. Technical and therapeutic advances have appeared in all areas of hepatology, in particular portal hypertension, liver tumours, genetic diseases and imaging, both diagnostic and therapeutic. All are brought up-to-date in the very readable style characteristic of this standard text.
*588  $aDescription based on publisher supplied metadata and other sources.
*588  $aElectronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
*650 0$aLiver -- Diseases..
*650 0$aBiliary tract -- Diseases.
*655 0$aElectronic books.
*700  $aDooley, James.
*77608$iPrint version:$aSherlock, Shiela$tDiseases of the Liver and Biliary System$dChichester : John Wiley & Sons, Incorporated,c2002$z9780632055821
*797  $aProQuest (Firm)
*85640$uhttps://ebookcentral.proquest.com/lib/vgregion/detail.action?docID=351079
^